[stevieturbo]

It provides much improved resistance to detonation allowing more timing where knock may have been a problem before.

And as you say, your fuel system does need to be able to accommodate the extra flow requirements.

Certainly nothing difficult using it, and tuning with it is no different to pump fuel.

It's quite popular with some guys here in the UK, although Ive only tried it recently on a few cars.
Personally I feel it is wasteful, as no matter what the driving style, the methanol is getting used.
But on the flip side there is no risk of a methanol injection system not working, because it's always there.