1S system work on a blown 5.0 Mustang

[davidmano1]

This is my race car and I have a Vortech S trim HO 13lbs. Of boost. Was going to do an Intercooler but like the idea of watercooling instead. Will a 1S system work or will I need to do the 2S system. I have a 1S now, can I just upgrade it to the 2S or will the 1S suffice.
Stock bottom end, TFS heads, cam, intake, 30lb injectors, no cats, full headers. This is a Road Race car not a drag racer. So boost will be on a lot of the time.
Any help would be great.

Thanks,
David