I found a nozzle per runner gave me the best results on a log style manifold, link to a pic here
http://members.aol.com/chappyrouter/gto/pics/4.jpg.
If you`re running mainly methanol you may be able to get away with 1 or 2 jets but water does`t like the log manifolds in my experience.
4 0.3mm port injectors should work well for you, do you know your max fuel flow?.